3-(Difluoromethyl)azetidine hydrochloride

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3-(Difluoromethyl)azetidine hydrochloride structure
Structural Feature
Azetidine scaffold
Reactive Feature
Difluoromethyl group Hydrochloride salt
Synthesis Role
Fluorinated heterocyclic building block
Application Context
Pharmaceutical intermediate
CAS Number1354792-76-9
EC/List No.855-263-1
Molecular FormulaC4H8ClF2N
Molecular Weight143.56 g/mol
SMILESCl.FC(F)C1CNC1
InChIKeyNYMQWAUMUHQGQQ-UHFFFAOYSA-N
Description3-(Difluoromethyl)azetidine hydrochloride, a difluoromethyl azetidine HCl salt. The difluoromethyl group serves as a hydroxymethyl bioisostere while enhancing lipophilicity.
ApplicationsPharmaceutical intermediate; azetidine; fluorinated
Hazard ClassAcute Tox. 4 (Oral)
Hazard StatementsH302
Precautionary StatementsP264; P270; P301+P312; P330; P405; P501