1-Tert-butyl 3-methyl 3-hydroxyazetidine-1,3-dicarboxylate

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1-Tert-butyl 3-methyl 3-hydroxyazetidine-1,3-dicarboxylate structure
Structural Feature
Azetidine scaffold
Reactive Feature
Boc-protected amine Methyl ester Tertiary alcohol
Synthesis Role
Protected heterocyclic intermediate
Application Context
Pharmaceutical intermediate
CAS Number1884303-05-2
EC/List No.825-351-4
Molecular FormulaC10H17NO5
Molecular Weight231.25 g/mol
SMILESCOC(=O)C1(O)CN(C(=O)OC(C)(C)C)C1
InChIKeyWSGWPDZGNJTWIB-UHFFFAOYSA-N
Description1-tert-Butyl 3-methyl 3-hydroxyazetidine-1,3-dicarboxylate, a hydroxy azetidine dicarboxylate. The Boc/methyl ester dual protection allows selective deprotection.
ApplicationsPharmaceutical intermediate; azetidine; Boc-protected
Hazard ClassAcute Tox. 4 (Oral); Skin Irrit. 2; Eye Irrit. 2A
Hazard StatementsH302; H315; H319
Precautionary StatementsP264; P270; P280; P301+P312; P302+P352; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P405; P501

Calculated / Predicted Properties

Estimated Boiling Point296.1 °C (predicted)
Estimated Density1.268 g/cm³ (predicted)